We recommend shorting Mirati Theraputics (NASDAQ:MRTX), which has a market cap of $3.4bn and $485m. Mirati had a huge run up since ASCO in June 2019 when the market got excited over Amgen’s release of an early cut of phase 1 data with AMG 510. Mirati’s share price jumped from $70 to $100+ in June on the hype adding around $1bnto the market cap. The bump allowed Mirati to raise $204m in a secondary priced at $97 per share.
Mirati’s KRAS product candidate MRTX849 is an oral KRAS G12C inhibitor similar to Amgen’s AMG510 and given lofty expectations, we expect results to disappoint. At $87 we think that MRTX shares are still a good shortand should sell off based on the Amgen dataand on the release of clinical data in Q4 2019.
Mirati is a pre-revenueclinical stage oncology company, whose clinical and pre-clinical programs consist of two main product candidates: itravatinib, a multi-kinase inhibitor and MRTX849, and an oral KRAS G12C inhibitor.Similar to AMG510, MRTX 849 is an orally available small molecule designed to target the KRAS G12C mutated protein. Mirati received an FDA approval of its IND for MRTX849 in November 2018 and in January 2019 started dosing the first patient the first patient in the dose escalation phase of a phase 1/2 clinical trial. Mirati's Phase 1/2 clinical trial will evaluate MRTX849 as a single agent in patients with advanced solid tumors that harbor KRAS G12C mutations. A dose expansion phase is planned to follow the selection of a recommended Phase 2 dose.Mirati plans to release a clinical data update in Q4 2019.
The KRAS G12C market opportunity is estimated to be$7 bn in the US and the EU($4.9 bn for NSCLC, $2.2bn for CRC, and $400m for Pancreatic). Following the release of the Amgen data in June, SunTrust raised the probability adjusted peak sales for MRTX849 from $1.3bn to $1.65bn with a probability of success of 52%.The peak sales estimate would assume that MRTX849takes almost 30% of the market, which is lofty given the number of competitors in the space.
Amgen Update
Over the weekend, Amgen released underwhelming data on the ongoing Phase 1 study evaluating AMG 510 in patients with previously treated KRAS G12C mutated solid tumors. AMG510 is an investigational oral therapy designed to target the KRAS G12C protein.
Amgen’s Phase 1 study for AMG510enrolled 35 patients with various tumor types (14 non-small cell lung cancer [NSCLC], 19 colorectal cancer [CRC] and two other). The primary treated tumor types were non-small cell lung cancer (NSCLC) and colorectal cancer (CRC), which have the highest incidence of KRAS G12C mutations. KRASG12C accounts for approximately 13% of NSCLC and 3-%-5% of CRC cases.Unlike patients with other mutations, such as HER2 or BRAF, patients with KRAS-mutated cancers still don’t have a treatment tailored to their mutation, largely due to the lack of obvious binding sites on the KRAS proteins.Patientsin the trialwere enrolled in four dose cohorts - 180 mg, 360 mg, 720 mg and 960 mg, taken orally once a day.
The initial headline findings presented at ASCOback in June (https://www.amgen.com/media/news-releases/2019/06/amgen-announces-first-clinical-data- evaluating-novel-investigational-krasg12c-inhibitor-amg-510-at-asco-2019/) showed that in 10 evaluable NSCLC patients, 5 experienced a partial response (PR), and another four had stable
disease (SD), for an objective response rate (OCR) of 90 percent (9/10).In other words, the drug shrank tumors in 50% (5/10) of the NSCLC patients and stopped tumor growth in 40% (4/10). All of the patients given the 960 mg dose (3/3) had a partial response or a 100% OCRfor this subset.
The additional follow-up in a larger group of patients being presented at WCLC next week shows that thirteen of the evaluableNSCLCpatients received the target dose of 960 mg(10 additional patients since ASCO), of which 54% (7/13) achieved a partial response and 46%(6/13)achieved stable disease.
However, compared to the earlier June results we seefor this larger sampleof patientsa (1) significant drop in the objective response rate for patients given the highest 960mg doseto 54% (7/13)from 100% (3/3) at ASCO in June and only 40% (4/10) for the new patients treated since ASCO with the 960mg dose and (2) a high relapse rate for patients with partial responses (PR) with 3 patients relapsingin a relatively shorttime periods(blue and pink dotson the graph).
I do not hold a position with the issuer such as employment, directorship, or consultancy. I and/or others I advise do not hold a material investment in the issuer's securities.
Are you sure you want to close this position MIRATI THERAPEUTICS INC?
By closing position, I’m notifying VIC Members that at today’s market price, I no longer am recommending this position.
Flag MIRATI THERAPEUTICS INC for Removal
Are you sure you want to Flag this idea MIRATI THERAPEUTICS INC for removal?
Flagging an idea indicates that the idea does not meet the standards of the club and you believe it should be removed from the site. Once a threshold has been reached the idea will be removed.
You Cannot Submit Message ... Yet
You currently do not have message posting privilages, there are
1 way you can get the privilage.
You can apply for full membership by submitting an investment idea of your own. Or if you are in reactivation status, you need to reactivate your full membership.